European Mind & Metabolism Association

One of the most recent research focuses of EMMA is the Serotonin 7 Receptor (INTEREST IS active AND EVER WILL BE) ... with a special focus on new agonist drugs.

5-HT7 receptor has been investigated under the ADHD-sythe project (2009-2012) and also under the NeuroGenMRI project (2011-2014), both led by Dr. W. Adriani for Italy. Both projects now closed. Check the PRECLINICAL goals achieved by "ADHD-sythe" project -or- See the CLINICAL goals of "NeuroGenMRI" project.

22-March-2018 | EMMA's people's articles:
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice -BY- Adriani, W., Travaglini, D., Lacivita, E., Saso, L., Leopoldo, M., Laviola, G.
and
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats -BY- Ruocco, L.A., Romano, E., Treno, C., lacivita, E., Claudio, A., Gironi-Carnevale, U.A., Travaglini, D., Leopoldo, M

have been cited in:

Downregulation of 5-hydroxytryptamine7receptor in the medial prefrontal cortex ameliorates impulsive actions in animal models of schizophrenia BY Zhang, W., Liu, J., Feng, J., Jia, M., Zhang, G., Wen, X.
Behavioural Brain Research, volume 341, issue , year 2018, pp. 212 - 223

We announce an upcoming TOPIC (Go!) for Frontiers in Behavioral Neuroscience : it will be guest edited by Dr Walter ADRIANI and Prof Carla PERRONE-CAPANO, and will call for papers (opinions, commentaries, original research investigations, mini- or regular reviews) allowing to focus on the Further Understanding of Serotonin Seven (5-HT7) Receptors’ Neuro-Psycho-Pharmacology (Quick overlook, through the EMMAweb frame). 

 Below, you will find the announcement of relevant papers, published in scientific journals, about the role of 5-HT7 receptors in neuropsychiatry.

 We announce two recent reviews:   

Di Pilato P, Niso M, Adriani W, Romano E, Travaglini D, Berardi F, Colabufo NA, Perrone R, Laviola G, Lacivita E, Leopoldo M ( 2014 link through DOI ). Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. Reviews in the Neurosciences. Published: Mar 13. 

Romano E, Ruocco LA, Nativio P, Lacivita E, Ajmone-Cat MA, Boatto G, Nieddu M, Tino A, Sadile AG, Minghetti L, Passarelli F, Leopoldo M, Laviola G, Adriani W ( 2014 link through DOI ). Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. Reviews in the Neurosciences. Published: Mar 6.

 and, in the same Special Issue:

Gasbarri A, Pompili A ( 2014 link through DOI ). Serotonergic 5-HT7 receptors and cognition. Reviews in the Neurosciences. Published: Feb 1.

 F. Kobe, D. Guseva, T.P. Jensen, ... and E. Ponimaskin (2013 - link to DOI) 5-HT7R / G12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner. The Journal of Neuroscience.

 Fan L.L., Zhang Q.J., Liu J., Feng J., Gui Z.H., Ali U., Zhang L., Hou C., Wang T., Hui Y.P., Sun Y.N., Wu Z.H. (2011 link to DOI). In vivo effect of 5-HT7 receptor agonist on pyramidal neurons in medial frontal cortex of normal and 6-hydroxy-dopamine-lesioned rats: an electro-physiological study. Neuroscience. 190: 328-38.